The Histamine Discovery Panel tests three markers that most practitioners never check.
Order the Histamine Discovery PanelYou've Googled your symptoms at midnight. You've gone down rabbit holes on social media. You've been in the Facebook groups, posted about the symptom nobody could explain, and gotten fifty replies with fifty different answers. Half of them telling you to find your root cause. And you're sitting there thinking: yes, but how?
You've tried the supplements. You've done elimination diets. You've gone back to your doctor and been told with a shrug that your labs are normal, you should work on your stress, maybe try an antidepressant, maybe it's just perimenopause.
Here's what nobody told you: histamine reactivity and leaky gut are almost never tested in a standard workup. They don't show up on a CBC or a metabolic panel. Your labs can be completely normal while your gut is actively driving every symptom you've been trying to explain for years.
That's not a stress problem. That's measurable, and it can be addressed.
The Histamine Discovery Panel tests zonulin, DAO, and histamine: the markers that show whether leaky gut is present and whether your body is clearing histamine the way it should. You collect the sample at home with a simple finger prick. While your sample is processing, you'll receive a short email series walking you through each marker, what it measures, what patterns to look for, and what it looks like when something is off. When your results arrive, you'll already know how to read them.
A lot of women describe getting their results as the first time something actually showed up on lab work in black and white. Not probably or maybe or have you tried yoga. Actual data, with an actual explanation.
The Intestinal iQ by Fluids iQ measures the three markers most directly connected to histamine reactivity and leaky gut. It ships to you as a dried blood spot kit. A finger prick, a prepaid return envelope, and results in 7 to 10 business days.
Zonulin is the protein that controls the tight junctions of your gut lining. Those junctions are what keep the good stuff in your bloodstream and the bad stuff out. When Zonulin is elevated, those junctions open when they shouldn't. Bacteria, food particles, and other triggers can cross into circulation, setting off inflammation, food sensitivities, and immune reactions. This is what leaky gut actually means, and this is the first test to measure it with a real biomarker.
Fluids iQ was the first lab to bring this test to North America. Elevated Zonulin is also directly connected to autoimmune thyroid activity, including Hashimoto's.
Histamine is a chemical messenger your immune system produces. In normal amounts it does important jobs. When it accumulates, it drives a wide range of symptoms that look random but aren't. A compromised gut lining increases histamine production while simultaneously reducing your body's ability to clear it. That combination is why so many people with gut issues end up reactive to foods, environments, and stress in ways that feel completely unpredictable.
DAO is the enzyme responsible for breaking down histamine in your gut. When your gut is inflamed, DAO production often drops, which means histamine builds up regardless of how careful you are with your diet. This is the piece most people are missing. It's not always that you're eating too much histamine. It's often that your body can't clear what's already there. And here's where the thyroid connection comes in: hypothyroidism suppresses DAO production, which means thyroid dysfunction can make histamine intolerance significantly worse even when diet is clean.
Low DAO is often why a low-histamine diet helps some but never fully resolves symptoms on its own.
This is the most useful number on the panel. A high ratio means there's more histamine circulating than your DAO can manage. It tells us whether the problem is high histamine, low DAO, or both. That distinction changes what comes next.
The ratio is what turns a data point into a direction.
Thyroid function and histamine clearance are directly linked. Hypothyroidism, including subclinical cases and Hashimoto's, suppresses DAO production, which means your body clears histamine less efficiently even before diet enters the picture. A leaky gut lets immune triggers into circulation, which can drive autoimmune thyroid activity. And gut inflammation disrupts the absorption of nutrients your thyroid depends on to function at all.
This is why so many women with thyroid conditions still react to foods, feel wired and tired, and can't figure out why their symptoms keep shifting. The gut piece is almost always involved. This test gives us a direct look at it.
A lab result without context is just a number. The educational series is what teaches you how to read yours.
At-home dried blood spot. Tests Zonulin, DAO, Histamine, and the Histamine:DAO ratio. Kit ships to you with prepaid return label. No lab visit needed.
While your sample is processing, you'll receive a short series walking you through each marker: what it measures, what patterns to look for, and what it looks like when something is off.
When your results are ready, you'll receive them directly. By the time they arrive, you'll already have the context to understand what you're looking at.
If you want Jen to review your results and map out a plan based on what shows up, a follow-up is available to panel buyers at a reduced rate.
$297 · Test kit and educational series included.
Finding a functional medicine practitioner who tests for leaky gut and histamine reactivity typically means an initial consultation ranging from $300 to over $1,000, labs ordered at additional cost, and a follow-up visit to go over results.
The Histamine Discovery Panel gives you the test and the education to understand it for less than most initial consultations alone.
Clicking the button above will take you to the secure Evexia lab checkout page to complete your order.
Important before you order:
The cost of the lab kit is non-refundable once your order is placed, as it is fulfilled directly through the lab.
New York, New Jersey, and Rhode Island: The Intestinal iQ test cannot be shipped to these states due to lab licensing restrictions. Please reach out before purchasing so we can discuss your options.
FSA/HSA may be applicable. Check with your plan administrator.
Your order covers the test kit and access to the educational series. You'll receive a welcome email within a few hours of purchase.
Your Intestinal iQ dried blood spot kit ships directly to you with step-by-step instructions and a prepaid return envelope. Most people finish the collection in under 10 minutes.
While your sample is processing, you'll receive a short email series walking you through each marker: what it measures, what patterns to watch for, and what it looks like when something is off. By the time your results arrive, you'll know how to read them.
When your results are ready, you'll receive them directly. You'll have the context from the email series to understand what the numbers mean.
Some women take their results and run. If you want Jen to review your results and map out a plan based on what shows up, a follow-up is available to panel buyers at a reduced rate.
If any of these describe you, this panel is worth considering. You don't need to check every box.
M.S. Nutrition | FDN Practitioner | Advanced Functional Lab Training
I wrote my master's thesis on Hashimoto's. That's not a detail I drop for credibility. It's the reason I ended up here. When you spend years deep in the research on why women with thyroid conditions still feel awful despite treatment, you keep finding the same thing: the gut piece is almost always involved, and almost nobody is looking at it.
I'm also a Functional Diagnostic Nutrition Practitioner with advanced lab training. That means when I built the educational series that comes with your results, I wasn't summarizing general information. I was teaching you how to read the same patterns I look for with clients.
I came to this work through my own experience with complex, hard-to-explain symptoms. The histamine-gut-thyroid connection isn't something I stumbled across. It's what I kept finding, in my own case and in clients who had tried everything else.
The Intestinal iQ uses a dried blood spot. The kit ships to you with a small lancet for a finger prick, collection cards, and a prepaid return envelope. Step-by-step instructions are included. Most people are done in 10 minutes or less. No lab visit, no appointment, no blood draw required.
More markers isn't always more clarity. Zonulin, DAO, and Histamine are the three markers that speak most directly to leaky gut and your body's ability to clear histamine. The test also calculates the Histamine:DAO ratio, which is often the most useful number of all. Paired with the educational series that walks you through how to read each one, that picture is specific enough to tell you where to focus.
That's still useful information. Normal results in the presence of significant symptoms usually point somewhere worth investigating. The educational series will help you understand what normal actually means for each marker and what to consider next.
These are self-pay labs. Insurance doesn't typically cover functional testing. Some clients use FSA or HSA funds. Check with your plan administrator.
No. As an FDNP, I have professional accounts with functional labs that allow clients to access testing they typically can't order on their own. What makes this different from ordering a test on your own is the education that comes with it. You'll receive a series that teaches you how to read your markers, recognize patterns, and understand what they mean for your symptoms.
Your results come with the context you need to understand them. The educational series covers each marker, common patterns, and what they tend to mean in combination. If you want Jen to review your results and map out a plan based on what shows up, a follow-up is available to panel buyers at a reduced rate.
Because the lab is ordered at the time of checkout, all sales are final. Please reach out before purchasing if you have any questions about whether this panel is the right fit for you.
No, and I want to be upfront about that. I hold a Master's degree in nutrition and advanced training in functional lab interpretation as an FDNP, but I'm not a licensed medical provider. This panel is for educational and informational purposes. I don't diagnose or treat medical conditions. What I do is give you access to testing and the education to understand what your markers show. I always recommend continuing to work with your licensed healthcare provider.
This test won't give you everything. It will give you a real starting point. Your actual numbers, plus the education to understand what they mean.
Order the Histamine Discovery Panel · $297